时间：2025年10月13日（周一）下午14:00

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主讲人：Ta Yuan Chang, Ph.D. 美国国家科学院院士；Catherine Chang, Ph.D. 美国达特茅斯学院医学院首席研究科学家

题目：Acyl-CoA: Cholesterol Acyltransferase 1:Cell biology, Biochemistry, and Medical Physiology

主讲人简介：

Ta Yuan Chang博士是达特茅斯学院医学院生物化学和细胞生物学系教授，2021年当选美国国家科学院外籍院士，他的研究专注于中枢神经系统和全身组织中胆固醇稳态平衡的调控机制，通过揭示相关分子作用路径，探索其在阿尔茨海默病等神经退行性疾病中的潜在治疗应用。Catherine Chang博士是达特茅斯学院医学院生物化学和细胞生物学系首席研究科学家。Drs. Chang实验室聚焦于胆固醇稳态平衡的调控机制，旨在开发治疗阿尔茨海默病等疾病的创新疗法。

Brief Introduction of Drs. Chang

Drs. Chang’s laboratory at Dartmouth has been working on cellular cholesterol metabolism in health and in diseases for many years. Our laboratory identified the gene that encodes the cholesterol storage enzyme acylcoenzyme A:cholesterol acyltransferase 1 (ACAT1). ACAT1 is an enzyme responsible for intracellular cholesterol esterification and storage. It is a membrane bound protein located at the endoplasmic reticulum, and plays important roles in health and in diseases. We are conducting structure-function analysis of ACAT1 in vitro, and taking mouse genetic approaches to determine the pathophysiological role of ACAT1 in Alzheimer’s disease, in atherosclerosis, and in diet-induced obesity. In addition, our lab has been involved in using mutant cell lines to dissect discrete steps in intracellular cholesterol trafficking.

承办单位：生命科学学院、泰康生命医学中心